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PST3093

Chemical Structure : PST3093

CAS No.: 2805980-42-9

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PST3093 (PST 3093)

Catalog No.: PC-49733Not For Human Use, Lab Use Only.

PST3093 (PST 3093) is the main Istaroxime metabolite and a selective SERCA2a activator, reduces the SERCA2a KdCa value by about 20% at 100 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PST3093 (PST 3093) is the main Istaroxime metabolite and a selective SERCA2a activator, reduces the SERCA2a KdCa value by about 20% at 100 nM.
    PST3093 shows a longer half-life in human circulation compared with parent drug Istaroxime.
    PST3093 did not inhibit the Na+/K+ ATPase activity up to 100 µM, and no INaK inhibition.
    PST3093 and istaroxime equally stimulated SERCA2a ATPase activity in preparations including PLN.
    PST3093 selectively activates SERCA2a, and improves cardiac performance in a model of diabetic cardiomyopathy.

    Physicochemical Properties

    M.Wt 377.48
    Formula C21H31NO5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (E,Z)-[(6-beta-hydroxy-17-oxoandrostan-3-ylidene)amino]oxyacetic acid

    References

    1. Martina Arici, et al. J Pharmacol Exp Ther. 2023 Jan;384(1):231-244.

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