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Chemical Structure : VK-II-36
CAS No.: 955371-66-1
Catalog No.: PC-38452Not For Human Use, Lab Use Only.
VK-II-36 is a carvedilol analogue that suppresses sarcoplasmic reticulum (SR) Ca(2+) release and does not block the β-receptor, via direct action on the cardiac ryanodine receptor type 2 (RyR2).
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|---|---|---|---|
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $348 | In stock | |
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VK-II-36 is a carvedilol analogue that suppresses sarcoplasmic reticulum (SR) Ca(2+) release and does not block the β-receptor, via direct action on the cardiac ryanodine receptor type 2 (RyR2).
VK-II-36 effectively suppressed spontaneous intracellular Ca(2+) elevations (SCaEs) and eliminated TAs observed in both mouse and rabbit ventricles.
VK-II-36 inhibits ventricular tachyarrhythmias in intact mouse and rabbit ventricles by the suppression of SCaEs, independent of beta-blocking activity.
| M.Wt | 446.50 | |
| Formula | C26H26N2O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
6-[(9H-Carbazol-4-yloxy)methyl]-4-[2-(2-methoxyphenoxy)ethyl]-3-morpholinone |
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1. Maruyama M, et al. Heart Rhythm. 2013 Jan;10(1):101-7.
2. Shinohara T, et al. Heart Vessels. 2014 May;29(3):396-403.
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