Catalog No.: PC-49242Not For Human Use, Lab Use Only.
TPC2-A1-P is a membrane permeable isoform-selective small molecule agonist agonist of two-pore channel 2 (TPC2) with EC50 of 10.5 uM in cell-based Ca2+ signals assays, mediates changes in intracellular calcium in the absence of extracellular calcium.
TPC2-A1-P is a membrane permeable isoform-selective small molecule agonist agonist of two-pore channel 2 (TPC2) with EC50 of 10.5 uM in cell-based Ca2+ signals assays, mediates changes in intracellular calcium in the absence of extracellular calcium.
TPC2-A1-P evokes Na+ currents in isolated endo-lysosomes with EC50 of 0.6 uM in endo-lysosomal patch-clamp experiments.
TPC2-A1-P but not TPC2-A1-N promoted lysosomal exocytosis.
TPC2-A1-N increases the pH in the lysosomal lumen in a TPC2-dependent manner, TPC2-A1-P has no significant effect on lysosomal pH.
