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Chemical Structure : TPC2-A1-P
CAS No.: 2804595-86-4
Catalog No.: PC-49242Not For Human Use, Lab Use Only.
TPC2-A1-P is a membrane permeable isoform-selective small molecule agonist agonist of two-pore channel 2 (TPC2) with EC50 of 10.5 uM in cell-based Ca2+ signals assays, mediates changes in intracellular calcium in the absence of extracellular calcium.
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|---|---|---|---|
| 5 mg | $258 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $598 | In stock | |
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TPC2-A1-P is a membrane permeable isoform-selective small molecule agonist agonist of two-pore channel 2 (TPC2) with EC50 of 10.5 uM in cell-based Ca2+ signals assays, mediates changes in intracellular calcium in the absence of extracellular calcium.
TPC2-A1-P evokes Na+ currents in isolated endo-lysosomes with EC50 of 0.6 uM in endo-lysosomal patch-clamp experiments.
TPC2-A1-P but not TPC2-A1-N promoted lysosomal exocytosis.
TPC2-A1-N increases the pH in the lysosomal lumen in a TPC2-dependent manner, TPC2-A1-P has no significant effect on lysosomal pH.
| M.Wt | 460.291 | |
| Formula | C20H21BrF3NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-(5-bromo-2-(trifluoromethoxy)phenyl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-carboxylic acid |
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1. Susanne Gerndt, et al. Elife. 2020 Mar 16;9:e54712.
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