Chemical Structure : KT-362
CAS No.:
105394-80-7
KT-362
Catalog No.: PC-24336Not For Human Use, Lab Use Only.
KT-362 is a small molecule intracellular calcium antagonist, inhibits NE-induced contractions and IP accumulation.
Bulk size, bulk discount!
Welcome credit card payment!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
KT-362 is a small molecule intracellular calcium antagonist, inhibits NE-induced contractions and IP accumulation.
KT-362 (3 x 10(-6) to 3 x 10(-5) M) caused a dose-dependent decrease in the maximum upstroke velocity (Vmax) of the action potential without affecting the resting potential.
KT-362 has quinidine-like use-dependent inhibitory action on the fast sodium channel of cardiac muscles by the binding to the channel mainly during its activated state.
KT-362 also suppressed the slow action potential in K+ depolarized papillary muscles.
Physicochemical Properties
|
M.Wt
|
516.61
|
|
Formula
|
C26H32N2O7S
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
5-[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-1-oxopropyl]-2,3,4,5-tetrahydro-1,5-benzothiazepine fumarate
|
References
1. Ueyama N, et al. Chem Pharm Bull (Tokyo). 1997 Nov;45(11):1761-6.
2. Cheng YN, et al. J Pharmacol Exp Ther. 1994 Sep;270(3):851-7.
3. Kodama I, et al. J Pharmacol Exp Ther. 1991 Jul 1;258(1):332-8.
Contact Us
sales@probechem.com
