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You are here:Home-Chemical Inhibitors & Agonists-Membrane Transporter/Ion Channel-Calcium Channel -SN-89B
SN-89B

Chemical Structure : SN-89B

CAS No.:

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SN-89B

Catalog No.: PC-23294Not For Human Use, Lab Use Only.

SN-89B is a potent LRRC8 channel inhibitorsuppresses agonist-induced platelet activation and aggregation (IC50=840 nM).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SN-89B is a potent LRRC8 channel inhibitorsuppresses agonist-induced platelet activation and aggregation (IC50=840 nM).
SN-89B strongly inhibits ATP and ADP efflux elicited in response to hypotonic swelling in MEG-01 cells.
SN-89B significantly reduces agonist-induced human platelet aggregation, as well as phosphorylation of AKT1, AKT2, and GSK-3β.
SN-89B (50 mg/kg) significantly prolongs FeCl3-induced carotid arterial thrombosis in WT C57BL/6J mice.

Physicochemical Properties

M.Wt
Formula
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

References

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