TMDJ-035 | RyR2 inhibitor | Probechem Biochemicals

Chemical Structure : TMDJ-035

TMDJ-035 (TMDJ 035, TMDJ035)

Catalog No.: PC-21312Not For Human Use, Lab Use Only.

TMDJ-035 is the first highly potent and selective ryanodine receptor 2 (RyR2) inhibitor with EC50 of 13 nM, shows no effect on RyR1 and RyR3.

Packing	Price	Stock	Quantity
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Biological Activity

TMDJ-035 is the first highly potent and selective ryanodine receptor 2 (RyR2) inhibitor with EC50 of 13 nM, shows no effect on RyR1 and RyR3.
TMDJ-035 (30-100 nM) is effective in preventing generation of Ca2+ waves in cardiomyocytes without affecting action potential-induced Ca2+ transients.
TMDJ-035 is a promising candidate for drug development to treat potentially fatal RyR2-related cardiac arrhythmias.

Physicochemical Properties

M.Wt	347.30
Formula	C16H12F3N5O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(5-(3,5-Difluorophenyl)-2H-tetrazol-2-yl)-N-(4-fluorophenyl)-N-methylacetamide

References

1. Ishida R, et al. Eur J Med Chem. 2023 Oct 25;262:115910.

Overnight Delivery
Fast & Safe Delivery Worldwide
Rewards Program

About Us

Our Services

Site Map

Join with Us
Product Use Citations

Pharmacological Glossary Abbreviations

Abbreviations

Quality Manual

Inquiry Form
How to Order

Terms & Conditions

Credit Card Payment

Shipping Rates & Policies

Privacy Policy
sales@probechem.com

TMDJ-035 (TMDJ 035, TMDJ035)

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

Get Quote

* Indicates a Required FieldYour information is safe with us.