MRS1845 | SOCE channel inhibitor, Orai1 inhibitor

Chemical Structure : MRS1845

CAS No.: 544478-19-5

MRS1845 (N-propargyl-nitrendipine)

Catalog No.: PC-22078Not For Human Use, Lab Use Only.

MRS1845 is a selective store-operated Ca2+ channel (SOC) Orai1 inhibitor, inhibits SOC channel-dependent elevations of calcium with IC50 of 1.7 uM in HL-60 cells.

Packing	Price	Stock
5 mg	$118	In stock
10 mg	$178	In stock
25 mg	$298	In stock
50 mg	$498	In stock
100 mg		Get quote

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Biological Activity

MRS1845 is a selective store-operated Ca2+ channel (SOC) Orai1 inhibitor, inhibits SOC channel-dependent elevations of calcium with IC50 of 1.7 uM in HL-60 cells.
MRS1845 attenuates neutrophil function and postshock acute lung injury.

Physicochemical Properties

M.Wt	398.42
Formula	C21H22N2O6
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1-(prop-2-yn-1-yl)-1,4-dihydropyridine-3,5-dicarboxylate

References

1. Harper JL, et al. Biochem Pharmacol. 2003 Feb 1;65(3):329-38.

2. Cindy Lee, et al. J Trauma. 2005 Jul;59(1):56-63; discussion 63.

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MRS1845 (N-propargyl-nitrendipine)

Biological Activity

Physicochemical Properties

References

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