| Cat. No. |
Product Name |
Information |
| PC-22078 |
MRS1845
SOCE channel inhibitor, Orai1 inhibitor
|
MRS1845 is a selective store-operated Ca2+ channel (SOC) Orai1 inhibitor, inhibits SOC channel-dependent elevations of calcium with IC50 of 1.7 uM in HL-60 cells. |
| PC-38432 |
Zegocractin
Orai1 channel inhibitor
|
Zegocractin (CM-4620, CM-128) is a selective small molecule CRAC (Orai1) channel inhibitor, inhibits Orai1/STIM1-mediated Ca2+ currents and Orai2/STIM1-mediated currents with IC50 of 120 nM and 900 nM, respectively. |
| PC-43089 |
GSK-5498A
CRAC channel inhibitor
|
GSK-5498A is a potent, selective small molecule blocker of Calcium-Release Activated Calcium (CRAC) channel with IC50 of 1 uM. |
| PC-60224 |
Synta66
CRAC channel inhibitor
|
Synta66 (Synta-66, GSK1349571A) is a potent, selective CRAC channel Orai1 blocker with IC50 of 3 uM. |
| PC-70096 |
GSK-7975A
Orai1 inhibitor
|
GSK-7975A (GSK7975A) is a selective CRAC channel essential pore subunit Orai1 blocker that inhibits store-operated Ca(2+) entry (SOCE) with IC50 of 3.4 uM. |
| PC-42271 |
YM-58483
CRAC channel inhibitor
|
YM-58483 is a potent store-operated Ca2+ entry blocker and CRAC channel inhibitor with IC50 of 100 nM. |
| PC-25758 |
RO2959 monohydrochloride
CRAC channel inhibitor
|
RO2959 monohydrochloride is a potent and selective CRAC channel inhibitor with IC50 of 402 nM, inhibits store operated calcium entry (SOCE) mediated by Orai1/Stim1 channels with IC50 of 25 nM, is also a potent inhibitor of human IL-2 production, and potently blocks T cell receptor triggered gene expression and T cell functional pathways. |
