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GSK-5498A

Chemical Structure : GSK-5498A

CAS No.: 1253186-49-0

GSK-5498A (GSK5498A)

Catalog No.: PC-43089Not For Human Use, Lab Use Only.

GSK-5498A is a potent, selective small molecule blocker of Calcium-Release Activated Calcium (CRAC) channel with IC50 of 1 uM.

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5 mg $288 In stock
10 mg $428 In stock
25 mg $728 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GSK-5498A is a potent, selective small molecule blocker of Calcium-Release Activated Calcium (CRAC) channel with IC50 of 1 uM.
GSK-5498A completely inhibits calcium influx through CRAC channels.
GSK-5498A inhibits mediator release from mast cells, and pro-inflammatory cytokine release from T-cells from multiple human and rat preparations.

Physicochemical Properties

M.Wt 399.2899
Formula C18H11F6N3O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Benzamide, 2,6-difluoro-N-[1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-1H-pyrazol-3-yl]-

References

1. Rice LV, et al. Eur J Pharmacol. 2013 Mar 15;704(1-3):49-57.

2. Chen J, et al. J Physiol. 2017 May 15;595(10):3203-3218.

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