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Chemical Structure : YM-58483
CAS No.: 223499-30-7
Catalog No.: PC-42271Not For Human Use, Lab Use Only.
YM-58483 is a potent store-operated Ca2+ entry blocker and CRAC channel inhibitor with IC50 of 100 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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YM-58483 is a potent store-operated Ca2+ entry blocker and CRAC channel inhibitor with IC50 of 100 nM.
YM-58483 inhibits Ca(2+) influx through SOC channels without affecting the TCR signal transduction cascade in Jurkat cells, inhibits thapsigargin-induced sustained Ca(2+) influx (IC50=100 nM), and 30-fold less potent against Cav channels.
YM-58483 potently inhibits IL-2 production and NF-AT-driven promoter activity in Jurkat cells.
YM-58483 also inhibits IL-4 and IL-5 production Th2 T cells, prevents antigen-induced inflammatory responses in animal models; orally active.
| M.Wt | 421.3203 | |
| Formula | C15H9F6N5OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 32 mg/mL |
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| Chemical Name/SMILES |
1,2,3-Thiadiazole-5-carboxamide, N-[4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methyl- |
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1. Ishikawa J, et al. J Immunol. 2003 May 1;170(9):4441-9.
2. Yoshino T, et al. Eur J Pharmacol. 2007 Apr 10;560(2-3):225-33.
3. Takezawa R, et al. Mol Pharmacol. 2006 Apr;69(4):1413-20.
4. Zitt C, et al. J Biol Chem. 2004 Mar 26;279(13):12427-37.
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