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Chemical Structure : Synta66
CAS No.: 835904-51-3
Catalog No.: PC-60224Not For Human Use, Lab Use Only.
Synta66 (GSK1349571A) is a potent, selective CRAC channel Orai1 blocker with IC50 of 3 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $178 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $488 | In stock | |
| 100 mg | Get quote |
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Synta66 (GSK1349571A) is a potent, selective CRAC channel Orai1 blocker with IC50 of 3 uM.
Synta66 does not impair other plasma membrane ion transporters; inhibits antigen-evoked Ca2+ influx in Fura-2-loaded cells at 10 uM, prevents the increase in Syk activity triggered by Ca2+ entry.
Synta66 reduces FcεRI-dependent Ca(2+) influx and the release of histamine, leukotriene C4, and cytokines (IL-5/-8/-13 and TNFα) by up to 50% at 3 uM in HLMCs.
| M.Wt | 352.37 | |
| Formula | C20H17FN2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(2',5'-Dimethoxy[1,1'-biphenyl]-4-yl)-3-fluoro-4-pyridinecarboxamide |
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1. Ng SW, et al. J Biol Chem. 2008 Nov 14;283(46):31348-55.
2. Ashmole I, et al. J Allergy Clin Immunol. 2012 Jun;129(6):1628-35.e2.
3. Nurbaeva MK, et al. Sci Rep. 2015 Oct 30;5:15803.
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