Chemical Structure : FPL64176
CAS No.:
120934-96-5
FPL64176
(ARC-64176;FPL-64176)
Catalog No.: PC-35298Not For Human Use, Lab Use Only.
FPL64176 (ARC-64176) is a potent L-type Ca++ channel activator with EC50 of 16 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
FPL64176 (ARC-64176) is a potent L-type Ca++ channel activator with EC50 of 16 nM; prolongs action potential duration and enhances contractility in guinea pig papillary muscle, induces contractile response with EC50 of 0.2 uM; produces biexponential tail current decays at -50 mV with fast and slow time constants of 4.30 +/- 0.30 and 44.52 +/- 4.56 msec, respectively; produces large increases in cardiac contractile force and diastolic blood pressure in anesthetized dogs (100 mg/kg, i.v.).
Heart Failure
Discontinued
Physicochemical Properties
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M.Wt
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347.414
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Formula
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C22H21NO3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2,5-Dimethyl-4-[2-(phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylic acid methyl ester
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References
1. Baxter AJ, et al. J Med Chem. 1993 Sep 17;36(19):2739-44.
2. Rampe D, et al. J Pharmacol Exp Ther. 1993 Jun;265(3):1125-30.
3. Zheng W, et al. Mol Pharmacol. 1991 Nov;40(5):734-41.
4. Liu L, et al. Neuropharmacology. 2003 Aug;45(2):281-92.
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