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Chemical Structure : CDN1163
CAS No.: 892711-75-0
Catalog No.: PC-35299Not For Human Use, Lab Use Only.
CDN1163 (CDN-1163) is a small molecule, allosteric activator of SERCA2, dose-dependently increases the Vmax of SERCA2 Ca2+-ATPase activity in ER microsomes.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $168 | In stock | |
| 100 mg | $368 | In stock | |
| 500 mg | $768 | In stock | |
| 1 g | Get quote |
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CDN1163 (CDN-1163) is a small molecule, allosteric activator of SERCA2, dose-dependently increases the Vmax of SERCA2 Ca2+-ATPase activity in ER microsomes.
CDN1163 increases Ca2+-ATPase activity and significantly enhances Ca2+ uptake into the ER, attenuates H2O2-stimulated cell death in HEK cells.
CDN1163 improves glucose homeostasis and metabolic parameters, increases glucose tolerance in ob/ob mice.
CDN1163 reduces lipid accumulation and decreases lipogenesis in obese mice livers.
| M.Wt | 320.392 | |
| Formula | C20H20N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
4-(1-Methylethoxy)-N-(2-methyl-8-quinolinyl)benzamide |
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1. Krajnak K, et al. Bioorg Med Chem Lett. 2018 May 15;28(9):1591-1594.
2. Kang S, et al. J Biol Chem. 2016 Mar 4;291(10):5185-98.
3. Dahl R. Bioorg Med Chem. 2017 Jan 1;25(1):53-57.
4. Cornea RL, et al. J Biomol Screen. 2013 Jan;18(1):97-107.
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