| Cat. No. |
Product Name |
Information |
| PC-20398 |
Rynaxypyr
RyR activator
|
Rynaxypyr (Chlorantraniliprole) is a highly potent and selective activator of insect ryanodine receptors (Hv RyR EC50=52 nM) with exceptional activity on a broad range of Lepidoptera. |
| PC-20397 |
RyR2 inhibitor EL9
RyR2 inhibitor
|
RyR2 inhibitor EL9 is a potent mutant RyR2 channel inhibitor, inhibits Ca2+ spark frequency (CaSF) in R176Q/+ myocytes with IC50 of 13 nM. |
| PC-20396 |
RyR2 inhibitor EL20
RyR2 inhibitor
|
RyR2 inhibitor EL20 is a potent antiarrhythmic compound, potently inhibits abnormal Ca2+ release in RyR2 R176Q myocytes with IC50 of 35.4 nM. |
| PC-20395 |
Cyantraniliprole
RyR activator
|
Cyantraniliprole (DPX-HGW86) is an insecticide of the ryanoid class, is a potent and selective anthranilic diamide ryanodine receptor (RyR) activator (Dipteran RyR, EC50=0.9 uM). |
| PC-20121 |
IPPQ
CaV2.2 inhibitor
|
IPPQ is a small molecule that selectively target the interface between the N-type calcium (CaV2.2) channel and CaVβ, specifically binds to CaVβ2a and inhibits CaVβ2's interaction with CaV.2-AID (alpha interacting domain). |
| PC-49748 |
HSK16149
VGCC α2δ ligand
|
HSK16149 (Crisugabalin) is a potent selective ligand of voltage-gated calcium channel (VGCC) α2δ subunit with IC50 of 3.96 nM in competitive [3H]gabapentin binding assays. |
| PC-49733 |
PST3093
SERCA2a activator
|
PST3093 (PST 3093) is the main Istaroxime metabolite and a selective SERCA2a activator, reduces the SERCA2a KdCa value by about 20% at 100 nM. |
| PC-49732 |
Istaroxime hydrochloride
Na-K ATPase inhibitor
|
Istaroxime (PST2744) is an inotropic agent and Na(+)/K(+)-ATPase inhibitor, inhibits dog kidney Na(+)/K(+)-ATPase with IC50 of 0.43 uM, also stimulates SERCA2a. |
| PC-47015 |
2E151
Calcium channel activator
|
2E151 is a small molecule calcium channel activator, increases murine antigen-specific antibody responses when used as a co-adjuvant with LPS. |
| PC-47014 |
2D216
Calcium channel activator
|
2D216 is a small molecule calcium channel activator, increases murine antigen-specific antibody responses when used as a co-adjuvant with LPS. |
| PC-38654 |
CRAC inhibitor 36
CRAC channel inhibitor
|
CRAC inhibitor 36 is a novel potent, selective calcium release-activated calcium (CRAC) channels inhibitor with IC50 of 11 nM (IL-2 inhibition) and 243 nM (SOCE inhibition). |
| PC-38485 |
VK-II-86
RyR2 inhibitor
|
VK-II-86 is a carvedilol analogue lacking antagonist activity at β-adrenoceptors, effectively suppresses SOICR by directly reducing the open duration of the cardiac ryanodine receptor (RyR2). |
