SN-407 | LRRC8 inhibitor | Probechem Biochemicals

Chemical Structure : SN-407

SN-407 (SN407)

Catalog No.: PC-23293Not For Human Use, Lab Use Only.

SN-407 is a potent VRAC inhibitor with IC50 of 1.6 uM in HEK cells, targets LRRC8 complex and blocks agonist-induced aggregation, ATP release, and calcium influx in platelets.

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Biological Activity

SN-407 is a potent VRAC inhibitor with IC50 of 1.6 uM in HEK cells, targets LRRC8 complex and blocks agonist-induced aggregation, ATP release, and calcium influx in platelets.

Physicochemical Properties

M.Wt	483.47
Formula	C26H36Cl2O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	7-((6,7-dichloro-2-cyclopentyl-1-oxo-2-pentyl-2,3-dihydro-1H-inden-5-yl)oxy)heptanoic acid

References

1. Tranter JD, et al. bioRxiv [Preprint]. 2024 Sep 26:2024.09.26.615233.

2. Lauren J Lahey, et al. Mol Cell. 2020 Nov 19;80(4):578-591.e5.

3. Gunasekar SK, et al. Nat Commun. 2022 Feb 10;13(1):784.

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SN-407 (SN407)

Biological Activity

Physicochemical Properties

References

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