| Cat. No. |
Product Name |
Information |
| PC-38772 |
C673-0105
USP10 inhibitor
|
C673-0105 is a selective, small molecule inhibitor of USP10, inhibits USP10 comparably to HBX19818 (IC50=10 uM), with no inhibition against USP7 (IC50>100 uM). |
| PC-38771 |
C598-0556
USP10 inhibitor
|
C598-0556 is a selective, small molecule inhibitor of USP10, inhibits USP10 comparably to HBX19818 (IC50=10 uM), with no inhibition against USP7 (IC50>100 uM). |
| PC-38692 |
FT709
USP9X inhibitor
|
FT709 is a potent, highly selective USP9X inhibitor with IC50 of 82 nM in biochemical assays, reduces CEP55 expression in BxPC3 pancreatic cancer cells with IC50 of 131 nM. |
| PC-38585 |
USP10 inhibitor Wu-5
USP10 inhibitor
|
USP10 inhibitor Wu-5 (Wu-5) is a novel small molecule USP10 inhibitor inducing the degradation of FLT3-mutated protein, directly interacts and inactivates USP10, the deubiquitinase for FLT3-ITD in vitro (IC50=8.3 uM) and in FLT3-ITD-positive AML cells. |
| PC-73355 |
Subquinocin
CYLD inhibitor
|
Subquinocin is a small molecule inhibitor of DUB activity of CYLD with IC50 of 30 uM, enhances NF-κB activation by inhibiting CYLD. |
| PC-73353 |
USP inhibitor 1
USP33 inhibitor
|
USP inhibitor 1 is an irreversible USP inhibitor with submicromolar IC50 of USP4 and its phylogenetic relative USP11, also functionally inhibits USP33, leading to CP110 instability and synergy with ATR inhibition. |
| PC-73318 |
KSQ-4279
USP1 inhibitor
|
KSQ-4279 (RO7623066) is a potent, selective, first-in-class inhibitor of USP1, shows anti-proliferative effects in a subset of cell lines, including mutations in BRCA1/2. |
| PC-73197 |
SJB2-043
USP1 inhibitor
|
SJB2-043 is a small molecule, specific USP1 inhibitor, inhibits USP1/UAF1 complex with IC50 of 0.544 uM. |
| PC-73132 |
6RK73
UCHL1 inhibitor
|
6RK73 is a potent, specific and covalent UCHL1 inhibitor with IC50 of 0.23 uM. |
| PC-72836 |
NJH-2-075
OTUB1 recruiter DUBTAC
|
NJH-2-075 is an alkyne-functionalized probe of EN523, retains binding to OTUB1 in vitro. |
| PC-72835 |
EN523
OTUB1 ligand
|
EN523 (EN-523) is a small molecule covalent ligand that targets a non-catalytic allosteric cysteine C23 in the K48-ubiquitin-specific deubiquitinase OTUB1, OTUB1 recruiter component of DUBTAC NJH-2-057. |
| PC-72699 |
MT16-001
UCHL1 inhibitor
|
MT16-001 is a selective, covalent inhibitor of deubiquitinating enzyme UCHL1 with IC50 of 580 nM, no inhibitory effect against UCHL3 (IC50>30 uM). |
