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Chemical Structure : BAY-805
CAS No.: 2925481-88-3
Catalog No.: PC-49862Not For Human Use, Lab Use Only.
BAY-805 (BAY805) is the first highly potent, selective and non-covalent USP21 inhibitor with IC50 of 6 nM and 2 nM in HTRF and Ub-rhodamine biochemical assays (hUSP21), respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $138 | In stock | |
| 10 mg | $218 | In stock | |
| 25 mg | $378 | In stock | |
| 50 mg | $588 | In stock | |
| 100 mg | Get quote |
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BAY-805 (BAY805) is the first highly potent, selective and non-covalent USP21 inhibitor with IC50 of 6 nM and 2 nM in HTRF and Ub-rhodamine biochemical assays (hUSP21), respectively.
Cellular inhibition of USP21 with BAY-805 induced cellular NF-κB activation with an EC50 of 17 nM in the NF-κB reporter assays.
BAY-805 shows the strong competition effect and effectively prevents ubiquitin binding.
BAY-805 exhibites strong ligand-induced protein stabilization resulting in a substantial thermal shift in the melt curve of USP21.
BAY-805 exhibits no antiproliferative effect was observed in Jurkat, Molm-13, A549, MDA-MB-231, and U2OS cell lines at 30 uM.
BAY-805 shows no significant effect on the activity of any of other deubiquitinating enzyme (DUBs) target.
| M.Wt | 507.58 | |
| Formula | C24H28F3N5O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-[(1R)-1-[[5-[(4-Cyanophenyl)methyl]-1,3,4-thiadiazol-2-yl]carbamoyl]-3-methyl-butyl]-1-(trifluoromethyl)cyclohexanecarboxamide |
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1. Fabian Göricke, et al. J Med Chem. 2023 Feb 20. doi: 10.1021/acs.jmedchem.2c01933.
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