Catalog No.: PC-49862Not For Human Use, Lab Use Only.
BAY-805 (BAY805) is the first highly potent, selective and non-covalent USP21 inhibitor with IC50 of 6 nM and 2 nM in HTRF and Ub-rhodamine biochemical assays (hUSP21), respectively.
BAY-805 (BAY805) is the first highly potent, selective and non-covalent USP21 inhibitor with IC50 of 6 nM and 2 nM in HTRF and Ub-rhodamine biochemical assays (hUSP21), respectively.
Cellular inhibition of USP21 with BAY-805 induced cellular NF-κB activation with an EC50 of 17 nM in the NF-κB reporter assays.
BAY-805 shows the strong competition effect and effectively prevents ubiquitin binding.
BAY-805 exhibites strong ligand-induced protein stabilization resulting in a substantial thermal shift in the melt curve of USP21.
BAY-805 exhibits no antiproliferative effect was observed in Jurkat, Molm-13, A549, MDA-MB-231, and U2OS cell lines at 30 uM.
BAY-805 shows no significant effect on the activity of any of other deubiquitinating enzyme (DUBs) target.
