| Cat. No. |
Product Name |
Information |
| PC-46007 |
SJB3-019A
USP1 inhibitor
|
SJB3-019A is a potent ubiquitin-specific protease USP1 inhibitor with IC50 of 78.1 nM, 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells. |
| PC-25571 |
OAT-4828 dihydrochloride
USP7 inhibitor
|
OAT-4828 dihydrochloride is a potent, and selective USP7 inhibitor with IC50 of 22 nM in enzymatic assay and 33 nM in reporter assay (Ub-CHOP reporter system). |
| PC-25550 |
USP19-IN-1
USP19 inhibitor
|
USP19-IN-1 (Example 124) is a potent, selective USP19 inhibitor with IC50 of <0.5 uM, high selective against a panel of 24 USPs and 19 other DUBs. |
| PC-25366 |
CAS-010
USP28 inhibitor
|
CAS-010 (CAS-13312-010) is a potent, selective and ubiquitin-competitive inhibitor of USP28 with IC50 of 4.2 nM in UbRho assays, disrupts the 53BP1-USP28 interaction and reduces p53 target gene transactivation. |
| PC-25142 |
USP10 inhibitor LY-2
USP10 inhibitor
|
USP10 inhibitor LY-2 is a potent ubiquitin-specific protease 10 (USP10) inhibitor with SPR binding KD of 365 nM and IC50 of 10.87 uM. |
| PC-25113 |
USP14 inhibitor AKOS
USP14 inhibitor
|
USP14 inhibitor AKOS (AKOSB018304) is a specific and covalent USP14 inhibitor with IC50 of 0.98 uM for USP14 deubiquitinase activity, also is a small molecule chikungunya virus (CHIKV) inhibitor. |
| PC-24885 |
Hyperoside
USP18 inhibitor
|
Hyperoside is a naturally occurring flavonol glycoside with anti-colitis and anticancer potential, also is a USP18 inhibitor that directly targets the USP18 IBB1 domain (BLI KD=7.04 uM), hyperoside inhibits PRRSV proliferation via the TLR4/NF-kappaB and p62-Nrf2-Keap1 signaling pathways. |
| PC-24867 |
Mitoxantrone
USP11 inhibitor
|
Mitoxantrone is a specific small molecule inhibitor of USP11 with IC50 of 3.15 uM, impacts PDA cell survival with an IC50<10 nM, also is a potent topoisomerase II inhibitor and inhibits protein kinase C (PKC) activity with IC50 of 8.5 uM. |
| PC-24793 |
STIRUR 41
USP7 inhibitor
|
STIRUR 41 (STIRUR-41, STIR UR 41) is a small molecule USP-7 inhibitor with IC50 of 2.77 uM in HTLA-230 cells, STIRUR 41 (5-10 uM) STIRUR 41 induces a remarkable decrease in USP-7 protein levels in HTLA-230 cells. |
| PC-24713 |
USP24-i-101
USP24 inhibitor
|
USP24-i-101 (Compound 677-8) is a specific small molecule inhibitor of USP24, induces autophagy in interphase and mitosis by inhibiting E2F4 and TRAF6, respectively. |
| PC-24549 |
TNG-6132
USP1 inhibitor
|
TNG-6132 is a potent, selective, reversible, allosteric and orally bioavailable USP1 inhibitor with pIC50 of 7.9 (USP1-UAF1 complex), and pIC50 of 7.6 in cellular viability assay with MDA-MB-436 cells. |
| PC-24536 |
NK036
USP30 inhibitor
|
NK036 is a solubility-enhanced derivative of USP30 inhibitor Compound 39 (CMPD-39), has IC50 of 7.4 nM and 4.1 nM for human USP30 (construct 1 (c1) and USP ch3, respectively. |
