Chemical Structure : USP14 inhibitor AKOS
CAS No.:
1784763-14-9
USP14 inhibitor AKOS
(AKOSB018304)
Catalog No.: PC-25113Not For Human Use, Lab Use Only.
USP14 inhibitor AKOS (AKOSB018304) is a specific and covalent USP14 inhibitor with IC50 of 0.98 uM for USP14 deubiquitinase activity, also is a small molecule chikungunya virus (CHIKV) inhibitor.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
USP14 inhibitor AKOS (AKOSB018304) is a specific and covalent USP14 inhibitor with IC50 of 0.98 uM for USP14 deubiquitinase activity, also is a small molecule chikungunya virus (CHIKV) inhibitor.
AKOS directly binds to USP14, covalently modifying the active-site cysteine residue (Cys114), thereby effectively inhibiting its deubiquitinase activity.
AKOS destabilizes its substrate MEF2D and inhibits the transcription of genes involved in the ECM-receptor interaction pathway in CRC.
AKOS significantly inhibited the proliferation and metastasis of CRC cells in vitro with IC50 values of 9.88 and 16.57 μM, respectively, in SW620 cells and HCT116 cells.
AKOS (15, 30 mg/kg, every 5 days) effectively suppressed the tumor growth in HCT116 xenograft mouse models in vivo.
Physicochemical Properties
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M.Wt
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266.29
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Formula
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C10H6N2O3S2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(E)-5-(2-nitrobenzylidene)-2-thioxothiazolidin-4-one
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References
1. Lu B, et al. Acta Pharmacol Sin. 2025 Jul 17. doi: 10.1038/s41401-025-01616-5.
2. Jadav SS, et al. Eur J Med Chem. 2015 Jan 7;89:172-8.
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