| Cat. No. |
Product Name |
Information |
| PC-45339 |
HBX-19818
USP7 inhibitor
|
HBX-19818 is a potent, selective USP7 inhibitor with IC50 of 28.1 uM. |
| PC-45856 |
USP8-IN-22d
USP8 inhibitor
|
USP8-IN-22d is a potent, selective ubiquitin-specific protease USP8 inhibitor with IC50 of 0.85 uM. |
| PC-45857 |
USP8-IN-22c
USP8 inhibitor
|
USP8-IN-22c is a potent, selective ubiquitin-specific protease USP8 inhibitor with IC50 of 0.56 uM. |
| PC-45056 |
USP7-IN-1
USP7 inhibitor
|
USP7-IN-1 is a novel selective and reversible inhibitor of USP7 with IC50 of 33 uM. |
| PC-46007 |
SJB3-019A
USP1 inhibitor
|
SJB3-019A is a potent ubiquitin-specific protease USP1 inhibitor with IC50 of 78.1 nM, 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells. |
| PC-24885 |
Hyperoside
USP18 inhibitor
|
Hyperoside is a naturally occurring flavonol glycoside with anti-colitis and anticancer potential, also is a USP18 inhibitor that directly targets the USP18 IBB1 domain (BLI KD=7.04 uM), hyperoside inhibits PRRSV proliferation via the TLR4/NF-kappaB and p62-Nrf2-Keap1 signaling pathways. |
| PC-24867 |
Mitoxantrone
USP11 inhibitor
|
Mitoxantrone is a specific small molecule inhibitor of USP11 with IC50 of 3.15 uM, impacts PDA cell survival with an IC50<10 nM, also is a potent topoisomerase II inhibitor and inhibits protein kinase C (PKC) activity with IC50 of 8.5 uM. |
| PC-24793 |
STIRUR 41
USP7 inhibitor
|
STIRUR 41 (STIRUR-41, STIR UR 41) is a small molecule USP-7 inhibitor with IC50 of 2.77 uM in HTLA-230 cells, STIRUR 41 (5-10 uM) STIRUR 41 induces a remarkable decrease in USP-7 protein levels in HTLA-230 cells. |
| PC-24713 |
USP24-i-101
USP24 inhibitor
|
USP24-i-101 (Compound 677-8) is a specific small molecule inhibitor of USP24, induces autophagy in interphase and mitosis by inhibiting E2F4 and TRAF6, respectively. |
| PC-24549 |
TNG-6132
USP1 inhibitor
|
TNG-6132 is a potent, selective, reversible, allosteric and orally bioavailable USP1 inhibitor with pIC50 of 7.9 (USP1-UAF1 complex), and pIC50 of 7.6 in cellular viability assay with MDA-MB-436 cells. |
| PC-24536 |
NK036
USP30 inhibitor
|
NK036 is a solubility-enhanced derivative of USP30 inhibitor Compound 39 (CMPD-39), has IC50 of 7.4 nM and 4.1 nM for human USP30 (construct 1 (c1) and USP ch3, respectively. |
| PC-24507 |
K-552
USP47 inhibitor
|
K-552 is a specific small molecule inhibitor of USP47 with Kd of 12.3 uM (cUSP47CD), shows more specific interactions with cUSP47CD than hUSP7CD. |
