| Cat. No. |
Product Name |
Information |
| PC-23075 |
JMS-175-2
BRISC inhibitor
|
JMS-175-2 is a specific, small molecule inhibitor Zn2+-dependent JAMM/MPN deubiquitylase (DUB) BRCC36 isopeptidase complex (BRISC) with IC50 of 3.8 uM. |
| PC-22953 |
MS5105
OTUB1 ligand
|
MS5105 is a small molecule OTUB1-covalent ligand, display improved effectiveness in covalently modifying OTUB1 compared with EN523, is useful for DUBTAC design. |
| PC-22885 |
USP7 inhibitor X36
USP7 inhibitor
|
USP7 inhibitor X36 is a potent, selective and orally active USP7 inhibitor with IC50 of 64.5 nM, shows no activity against a panel of 9 DUBs including USP47. |
| PC-22878 |
FLX4
USP7 inhibitor
|
FLX4 is a potent, selective and allosteric inhibitor of USP7 with IC50 of <1 uM. |
| PC-22877 |
YCH3124
USP7 inhibitor
|
YCH3124 is a potent, selective USP7 inhibitor with IC50 of 41.9 nM and Kd of 156 nM, exhibits minimal inhibition against other USPs, including USP1, USP4, USP8, USP9X, USP15, and USP25. |
| PC-22864 |
USP1 inhibitor C527
USP1 inhibitor
|
USP1 inhibitor C527 is a specific small-molecule inhibitor of USP1 blocking the deubiquitinating enzyme activity of USP1 with IC50 of 0.88 uM (USP/UAF1 complex). |
| PC-22863 |
Zerumbone
TAGLN/USP1 inhibitor
|
Zerumbone is a natural cyclic sesquiterpene and can be isolated from Zingiber zerumbet with anti-proliferative, anti-inflammation, anti-cancer, anti-bacterial and anti-mutagenic activity, binds to transgelin (TAGLN) and reduces the retention of USP1 in the cytoplasm and the degradation of ZEB1 ubiquitination. |
| PC-22320 |
Compound 7695-0983
FAT10 inhibitor
|
Compound 7695-0983 is a small molecule inhibitor of HLA-F locus-adjacent transcript 10 (FAT10), inhibits the expression of FAT10, inhibits NEDD4-PTEN/AKT axis-mediated autophagy. |
| PC-22319 |
IMP-2586
USP30 inhibitor
|
IMP-2586 is a potent, selective ubiquitin-specific protease 30 (USP30) inhibitor with IC50 of 16.3 nM, binding Ki of 5.6 nM. |
| PC-22318 |
IMP-2587
USP30 inhibitor
|
IMP-2587 is a potent, selective ubiquitin-specific protease 30 (USP30) inhibitor with IC50 of 12.6 nM, binding Ki of 42.7 nM. |
| PC-22313 |
USP10 inhibitor D1
USP10 inhibitor
|
USP10 inhibitor D1 is a potent, selective small molecule ubiquitin-specific protease 10 (USP10) inhibitor with IC50 of 7.2 uM, KD of 5.24 uM in microscale thermophoresis (MST)-based binding assay. |
| PC-22261 |
CT1113
USP28 inhibitor
|
CT1113 is a potent, selective small molecule USP25/USP28 inhibitor with IC50 of 26.1 nM/3.9 nM, respectively. |
