| Cat. No. |
Product Name |
Information |
| PC-20184 |
GSK2643943A
USP20 inhibitor
|
GSK2643943A is a specific, cell penetrant small molecule inhibitor of deubiquitinating enzyme USP20 with IC50 of 160 nM (USP20/Ub-Rho). |
| PC-20004 |
TG2-179-1
BAP1 inhibitor
|
TG2-179-1 is a potent, selective and covalently inhibitor of deubiquitinase (DUB) BRCA1-associated protein-1 (BAP1), covalently binds to the active site of BAP1 (Cys91), exhibits potent cytotoxic activity against colon cancer cells. |
| PC-49626 |
8RK64
UCHL1 inhibitor
|
8RK64 is a covalent small molecule inhibitor of ubiquitin carboxy-terminal hydrolase L1 (UCHL1, PGP9.5, PARK5) enzyme with IC50 of 0.32 uM, >80-fold selectivity over UCHL3 and UCHL5. |
| PC-49546 |
Usp22i-S02
USP22 inhibitor
|
Usp22i-S02 (Usp22 inhibitor S02) is a specific small-molecule inhibitor of the Foxp3-specific deubiquitinase USP22, down-regulates Foxp3 expression in Treg cells in a Usp22- but not Usp21-dependent manner. |
| PC-38585 |
USP10 inhibitor Wu-5
USP10 inhibitor
|
USP10 inhibitor Wu-5 (Wu-5) is a novel small molecule USP10 inhibitor inducing the degradation of FLT3-mutated protein, directly interacts and inactivates USP10, the deubiquitinase for FLT3-ITD in vitro (IC50=8.3 uM) and in FLT3-ITD-positive AML cells. |
| PC-73354 |
USP inhibitor 2
USP4 inhibitor
|
USP inhibitor 2 is a broad DUB inhibitor with IC50 of 0.04 and 0.21 uM for USP4 and USP11, also inhibits USP10/16/15/19 with submicromolar potency, forms a covalent adduct with USP11. USP inhibitor 2 does not inhibit USP5 (IC50>100 uM). |
| PC-73197 |
SJB2-043
USP1 inhibitor
|
SJB2-043 is a small molecule, specific USP1 inhibitor, inhibits USP1/UAF1 complex with IC50 of 0.544 uM. |
| PC-72534 |
USP8 inhibitor RA-9
USP8 inhibitor
|
USP8 inhibitor RA-9 is a small molecule USP8 inhibitor. |
| PC-72414 |
USP5 inhibitor 64
USP5 inhibitor
|
USP5 inhibitor 64 is a selective chemical probe (inhibitor) against USP5 deubiquitinase, binds to the USP5 ZnF-UBD (zinc-finger ubiquitin binding domain) with KD of 2.8 uM. |
| PC-72297 |
iBAP
BAP1 inhibitor
|
iBAP (BAP1 inhibitor I) is a first-in-class inhibitor of the catalytic activity of BAP1 histone H2A deubiquitinase complex with IC50 of 0.5-1 uM in vitro, |
| PC-72296 |
iBAP-II
BAP1 inhibitor
|
iBAP-II (BAP1 inhibitor II) is a next-generation, specific small molecule inhibitor of BAP1 histone H2A deubiquitinase activity with IC50 of <0.1 ug/mL. |
| PC-72255 |
USP30 inhibitor Q14 peptide
USP30 inhibitor
|
USP30 inhibitor Q14 peptide is a peptide derived from the transmembrane (TM) domain of USP30 that can target mitochondrial-anchored USP30 directly and increase mitophagy. |
