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Chemical Structure : ML364
CAS No.: 1991986-30-1
Catalog No.: PC-42288Not For Human Use, Lab Use Only.
ML364 is a potent, selective and reversible ubiquitin-specific protease USP2 inhibitor with IC50 of 1.1 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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ML364 is a potent, selective and reversible ubiquitin-specific protease USP2 inhibitor with IC50 of 1.1 uM.
ML364 also inhibits USP8 (IC50=0.95 uM), and no activity against caspase 6, caspase 7, MMP1, MMP9 and USP15, as well as a a panel of 102 kinases.
ML364 accelerates cellular cyclin D1 degradation and causes cell cycle arrest in HCT116 cancer cell lines, also causes a decrease in homologous recombination-mediated DNA repair.
| M.Wt | 517.5432296 | |
| Formula | C24H18F3N3O3S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 33 mg/mL |
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| Chemical Name/SMILES |
Benzamide, 2-[[(4-methylphenyl)sulfonyl]amino]-N-(4-phenyl-2-thiazolyl)-4-(trifluoromethyl)- |
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1. Davis MI, et al. J Biol Chem. 2016 Nov 18;291(47):24628-24640.
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