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ML323

Chemical Structure : ML323

CAS No.: 1572414-83-5

ML323 (ML-323, ML 323)

Catalog No.: PC-45341Not For Human Use, Lab Use Only.

ML323 (ML 323) is a potent, selective, reversible inhibitor of the USP1/UAF1 deubiquitinase complex with IC50 of 76 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ML323 (ML 323) is a potent, selective, reversible inhibitor of the USP1/UAF1 deubiquitinase complex with IC50 of 76 nM.
ML323 displays >1,500-fold selectivity versus USP2, USP5, USP7, USP8, and USP46/UAF1.
ML323 potentiates the cytotoxicity of cisplatin and increases endogenous monoubiquitination levels of both PCNA and FANCD2, two known cellular targets of USP1/UAF1.
ML323 possesses a promising in vitro ADME profile.

Physicochemical Properties

M.Wt 384.4769
Formula C23H24N6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
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Solubility

DMSO: ≥ 49 mg/mL

Chemical Name/SMILES

N-(4-(1H-1,2,3-triazol-1-yl)benzyl)-2-(2-isopropylphenyl)-5-methylpyrimidin-4-amine

References

1. Liang Q, et al. Nat Chem Biol. 2014 Apr;10(4):298-304.

2. Dexheimer TS, et al. J Med Chem. 2014 Oct 9;57(19):8099-110.

3. Sourisseau T, et al. Cell Cycle. 2016;15(2):295-302. doi: 10.1080/15384101.2015.1120918.

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