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Chemical Structure : ML323
CAS No.: 1572414-83-5
Catalog No.: PC-45341Not For Human Use, Lab Use Only.
ML323 (ML 323) is a potent, selective, reversible inhibitor of the USP1/UAF1 deubiquitinase complex with IC50 of 76 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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ML323 (ML 323) is a potent, selective, reversible inhibitor of the USP1/UAF1 deubiquitinase complex with IC50 of 76 nM.
ML323 displays >1,500-fold selectivity versus USP2, USP5, USP7, USP8, and USP46/UAF1.
ML323 potentiates the cytotoxicity of cisplatin and increases endogenous monoubiquitination levels of both PCNA and FANCD2, two known cellular targets of USP1/UAF1.
ML323 possesses a promising in vitro ADME profile.
| M.Wt | 384.4769 | |
| Formula | C23H24N6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 49 mg/mL |
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| Chemical Name/SMILES |
N-(4-(1H-1,2,3-triazol-1-yl)benzyl)-2-(2-isopropylphenyl)-5-methylpyrimidin-4-amine |
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1. Liang Q, et al. Nat Chem Biol. 2014 Apr;10(4):298-304.
2. Dexheimer TS, et al. J Med Chem. 2014 Oct 9;57(19):8099-110.
3. Sourisseau T, et al. Cell Cycle. 2016;15(2):295-302. doi: 10.1080/15384101.2015.1120918.
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