Catalog No.: PC-46007Not For Human Use, Lab Use Only.
SJB3-019A is a potent ubiquitin-specific protease USP1 inhibitor with IC50 of 78.1 nM, 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells.
SJB3-019A is a potent ubiquitin-specific protease USP1 inhibitor with IC50 of 78.1 nM, 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells.
SJB3-019A also increases the levels of Ub-FANCD2 and Ub-PCNA, and decreases the HR activity.
SJB3-019A triggers apoptosis in multiple myeloma cells via activation of caspase-3/8/9, degrades USP1 and downstream inhibitor of DNA-binding proteins as well as inhibits DNA repair via blockade of Fanconi anemia pathway and homologous recombination.
SJB3-019A downregulates multiple myeloma stem cell Notch-1, Notch-2, SOX-4, and SOX-2, and induces generation of more mature and differentiated plasma cells.
Physicochemical Properties
M.Wt
276.2463
Formula
C16H8N2O3
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
2-(pyridin-3-yl)naphtho[2,3-d]oxazole-4,9-dione
References
1. Mistry H, et al. Mol Cancer Ther. 2013 Dec;12(12):2651-62.
2. Das DS, et al. Clin Cancer Res. 2017 Mar 7. doi: 10.1158/1078-0432.CCR-16-2692.
