Chemical Structure : SJB3-019A
CAS No.: 2070015-29-9
Catalog No.: PC-46007Not For Human Use, Lab Use Only.
SJB3-019A is a potent ubiquitin-specific protease USP1 inhibitor with IC50 of 78.1 nM, 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells.
Packing | Price | Stock | Quantity |
---|---|---|---|
5 mg | $88 | In stock | |
10 mg | $128 | In stock | |
25 mg | $218 | In stock | |
50 mg | $358 | In stock | |
100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
SJB3-019A is a potent ubiquitin-specific protease USP1 inhibitor with IC50 of 78.1 nM, 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells.
SJB3-019A also increases the levels of Ub-FANCD2 and Ub-PCNA, and decreases the HR activity.
SJB3-019A triggers apoptosis in multiple myeloma cells via activation of caspase-3/8/9, degrades USP1 and downstream inhibitor of DNA-binding proteins as well as inhibits DNA repair via blockade of Fanconi anemia pathway and homologous recombination.
SJB3-019A downregulates multiple myeloma stem cell Notch-1, Notch-2, SOX-4, and SOX-2, and induces generation of more mature and differentiated plasma cells.
M.Wt | 276.2463 | |
Formula | C16H8N2O3 | |
Appearance | Solid | |
Storage |
|
|
Solubility |
10 mM in DMSO |
|
Chemical Name/SMILES |
2-(pyridin-3-yl)naphtho[2,3-d]oxazole-4,9-dione |
1. Mistry H, et al. Mol Cancer Ther. 2013 Dec;12(12):2651-62.
2. Das DS, et al. Clin Cancer Res. 2017 Mar 7. doi: 10.1158/1078-0432.CCR-16-2692.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright