Chemical Structure : NSC632839
CAS No.: 157654-67-6
Catalog No.: PC-42231Not For Human Use, Lab Use Only.
NSC632839 is a small molecule inhibitor of ubiquitin-proteasome system by inhibiting the ubiquitin isopeptidases, inhibits USP2, USP7, and SENP2 with EC50 values of 45 μM, 37 μM, and 9.8 μM, respectively.
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NSC632839 is a small molecule inhibitor of ubiquitin-proteasome system by inhibiting the ubiquitin isopeptidases, inhibits USP2, USP7, and SENP2 with EC50 values of 45 μM, 37 μM, and 9.8 μM, respectively.
NSC632839 induces a unique apoptotic pathway, which includes a Bcl-2-dependent but apoptosome-independent mitochondrial pathway with up-regulation of the BH3-only protein Noxa, stabilization of the IAP antagonist Smac, but also the involvement of the death receptor pathway.
M.Wt | 339.8585 | |
Formula | C21H22ClNO | |
Appearance | Solid | |
Storage |
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Solubility |
DMSO: 6.2 mg/mL (Need warming) |
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Chemical Name/SMILES |
4-Piperidinone, 3,5-bis[(4-methylphenyl)methylene]-, hydrochloride (1:1) |
1. Aleo E, et al. Cancer Res. 2006 Sep 15;66(18):9235-44.
2. Nicholson B, et al. Protein Sci. 2008 Jun;17(6):1035-43.
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