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NSC632839

Chemical Structure : NSC632839

CAS No.: 157654-67-6

NSC632839 (NSC-632839;NSC 632839;Ubiquitin Isopeptidase-IN-F6)

Catalog No.: PC-42231Not For Human Use, Lab Use Only.

NSC632839 is a small molecule inhibitor of ubiquitin-proteasome system by inhibiting the ubiquitin isopeptidases, inhibits USP2, USP7, and SENP2 with EC50 values of 45 μM, 37 μM, and 9.8 μM, respectively.

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Biological Activity

NSC632839 is a small molecule inhibitor of ubiquitin-proteasome system by inhibiting the ubiquitin isopeptidases, inhibits USP2, USP7, and SENP2 with EC50 values of 45 μM, 37 μM, and 9.8 μM, respectively.
NSC632839 induces a unique apoptotic pathway, which includes a Bcl-2-dependent but apoptosome-independent mitochondrial pathway with up-regulation of the BH3-only protein Noxa, stabilization of the IAP antagonist Smac, but also the involvement of the death receptor pathway.

Physicochemical Properties

M.Wt 339.8585
Formula C21H22ClNO
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: 6.2 mg/mL (Need warming)

Chemical Name/SMILES

4-Piperidinone, 3,5-bis[(4-methylphenyl)methylene]-, hydrochloride (1:1)

References

1. Aleo E, et al. Cancer Res. 2006 Sep 15;66(18):9235-44.

2. Nicholson B, et al. Protein Sci. 2008 Jun;17(6):1035-43.

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