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Chemical Structure : NSC632839
CAS No.: 157654-67-6
Catalog No.: PC-42231Not For Human Use, Lab Use Only.
NSC632839 is a small molecule inhibitor of ubiquitin-proteasome system by inhibiting the ubiquitin isopeptidases, inhibits USP2, USP7, and SENP2 with EC50 values of 45 μM, 37 μM, and 9.8 μM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $218 | In stock | |
| 100 mg | Get quote |
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NSC632839 is a small molecule inhibitor of ubiquitin-proteasome system by inhibiting the ubiquitin isopeptidases, inhibits USP2, USP7, and SENP2 with EC50 values of 45 μM, 37 μM, and 9.8 μM, respectively.
NSC632839 induces a unique apoptotic pathway, which includes a Bcl-2-dependent but apoptosome-independent mitochondrial pathway with up-regulation of the BH3-only protein Noxa, stabilization of the IAP antagonist Smac, but also the involvement of the death receptor pathway.
| M.Wt | 339.8585 | |
| Formula | C21H22ClNO | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 6.2 mg/mL (Need warming) |
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| Chemical Name/SMILES |
4-Piperidinone, 3,5-bis[(4-methylphenyl)methylene]-, hydrochloride (1:1) |
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1. Aleo E, et al. Cancer Res. 2006 Sep 15;66(18):9235-44.
2. Nicholson B, et al. Protein Sci. 2008 Jun;17(6):1035-43.
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