| Cat. No. |
Product Name |
Information |
| PC-63454 |
NSC112200
ZRANB1 inhibitor
|
NSC112200 is a chemical inhibitor of the EZH2 deubiquitinase ZRANB1 (at 10 uM), destabilizes EZH2, promotes proteasomal degradation of EZH2 and inhibits the viability of TNBC cells. |
| PC-43050 |
VLX1570
DUBs inhibitor
|
VLX1570 is a small molecule b-AP15 analog that fucttion as proteasome deubiquitinase inhibitor with IC50 of 10 uM, interacts at the active sites of the proteasome DUBs USP14 and UCHL5. |
| PC-62856 |
BRD0476
USP9X inhibitor
|
BRD 0476 (ML187) is a selective, moderate inhibitor of ubiquitin-specific peptidase 9X (USP9X), inhibits pancreatic β-cell apoptosis that inhibits IFN-γ-induced JAK2 and STAT1 signaling to promote β-cell survival. |
| PC-62623 |
IU1-47
USP14 inhibitor
|
IU1-47 is a potent, selective small-molecule inhibitor of USP14 with IC50 of 0.6 uM, shows 10-fold more potent over IU1 and retains specificity for USP14. |
| PC-62574 |
P217564
USP7 inhibitor
|
P 217564 is a potent, selective, irreversible second generation inhibitor of USP7 with IC50 of 0.48 uM, with similar potency against USP47 and no significant activity aginst other DUBs. |
| PC-62449 |
HBX 28258
USP7 inhibitor
|
HBX 28258 is a potent, selective USP7 inhibitor with IC50 of 22.6 uM, exhibits high selectivity over other USP members, such as USP8, USP5, USP2, and USP20 (IC50 >200 uM), and no activity against UCH-L1, UCH-L3 and SENP1. |
| PC-62189 |
Spautin-1
Autophagy inhibitor
|
Spautin-1 is a potent, small molecule inhibitor of autophagy with IC50 of 0.74 uM, inhibits USP10 and USP13 with IC50 of 0.6-0.7 uM, but not USP14. |
| PC-61936 |
LDN 91946
UCHL1 inhibitor
|
LDN 91946 is a selective, uncompetitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor with Ki of 2.8 uM, exhibits no activity against other cysteine hydrolase (UCH-L3, TGase 2, papain and caspase-3). |
| PC-61935 |
USP7i-1
USP7 inhibitor
|
USP7i-1 (USP7-IN-1) is a potent, selective USP7 inhibitor with IC50 of 77 uM. |
| PC-61934 |
USP10-IN-3
USP10 inhibitor
|
USP10-IN-3 is a HBX19818 analog, potent and selective USP10 inhibitor, but does not inhibit USP7 (IC50>100 uM). |
| PC-61933 |
USP10-IN-9
USP10 inhibitor
|
USP10-IN-9 is a HBX19818 analog, selective USP10 inhibitor with IC50 similar to HBX19818, but does not inhibit USP7 (IC50>100 uM).. |
| PC-61702 |
TCID
UCHL3 inhibitor
|
TCID is a selective ubiquitin C-terminal hydrolase-L3 (UCH-L3) inhibitor with IC50 of 0.6 uM, displays >100-fold selectivity over UCH-L1. |
