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Chemical Structure : XL177A
CAS No.: 2417089-74-6
Catalog No.: PC-38072Not For Human Use, Lab Use Only.
XL177A (XL-177A) is a potent, selective, irreversible USP7 inhibitor with IC50 of 0.34 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $488 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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XL177A (XL-177A) is a potent, selective, irreversible USP7 inhibitor with IC50 of 0.34 nM.
XL177A inhibits HA-Ub-VS labeling with IC50s of 85 and 8 nM following 30min and 4hr compound preincubations, respectively。
XL177A is a potent USP7 inhibitor (IC50=39 nM) and p53 stabilizer in cyto.
XL177A binds USP7 in the XL188 binding pocket, XL177A binds to and inhibits USP7 with >10-fold selectivity over closely related DUBs.
XL177A activates p53 signaling transcriptome-wide in MCF7 cells. XL177A exerts p53-dependent growth suppression in individual cell lines.
| M.Wt | 861.485 | |
| Formula | C48H57ClN8O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-N-(4-benzyl-5-(4-hydroxy-4-((7-(3-(4-methylpiperazin-1-yl)propanamido)-4-oxoquinazolin-3(4H)-yl)methyl)piperidin-1-yl)-5-oxopentyl)-9-chloro-5,6,7,8-tetrahydroacridine-3-carboxamide |
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1. Nathan J Schauer, et al. Sci Rep. 2020 Mar 24;10(1):5324.
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