Catalog No.: PC-62574Not For Human Use, Lab Use Only.
P 217564 is a potent, selective, irreversible second generation inhibitor of USP7 with IC50 of 0.48 uM, with similar potency against USP47 and no significant activity aginst other DUBs.
P217564 is a potent, selective, irreversible second generation inhibitor of USP7 with IC50 of 0.48 uM, with similar potency against USP47 and no significant activity aginst other DUBs.
P217564 exhibits 10-fold increase in potency compared to P5091, selectively targets the catalytic cleft of USP7 and modifies its active site cysteine (C223) by forming a covalent adduct.
P217564 downregulates Foxp3 and Tip60 in Treg cells and impairs Treg functions, increases polyubiquitination of Foxp3, Tip60 and USP7, induces dose- and time-dependent apoptosis of Jurkat cells.
