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Chemical Structure : BRD0476
Catalog No.: PC-62856Not For Human Use, Lab Use Only.
BRD 0476 (ML187) is a selective, moderate inhibitor of ubiquitin-specific peptidase 9X (USP9X), inhibits pancreatic β-cell apoptosis that inhibits IFN-γ-induced JAK2 and STAT1 signaling to promote β-cell survival.
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BRD 0476 (ML187) is a selective, moderate inhibitor of ubiquitin-specific peptidase 9X (USP9X), inhibits pancreatic β-cell apoptosis that inhibits IFN-γ-induced JAK2 and STAT1 signaling to promote β-cell survival.
BRD 0476 does not has kinase inhibitory activity, and no effect no effect on JAK1, JAK2, or JAK3 activities.
The deubiquitinase ubiquitin-specific peptidase 9X (USP9X) is an intracellular target of BRD0476.
| M.Wt | 674.769 | |
| Formula | C35H38N4O8S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chou DH, et al. J Am Chem Soc. 2015 Jun 24;137(24):7929-34.
2. Faloon PW, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].
3. Chou DH, et al. ACS Med Chem Lett. 2011 Sep 8;2(9):698-702.
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