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KL001

Chemical Structure : KL001

CAS No.: 309928-48-1

KL001 (KL-001;KL 001)

Catalog No.: PC-36022Not For Human Use, Lab Use Only.

KL001 (KL-001) is a small molecule that specifically interacts with cryptochrome (CRY) and small molecule modulator of the circadian clock.

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Biological Activity

KL001 (KL-001) is a small molecule that specifically interacts with cryptochrome (CRY) and small molecule modulator of the circadian clock.
KL001 prevents SCFFBXL3-mediated ubiquitination and degradation of CRY, resulting in lengthening of the circadian period, interacts directly with CRY1 and CRY2 and stabilizes CRY proteins.
KL001-mediated CRY stabilization inhibited glucagon-induced gluconeogenesis in primary hepatocytes.
KL001 is the first-in-class cryptochrome-targeting circadian modulator and substrate-targeting ubiquitination antagonist.

Physicochemical Properties

M.Wt 398.477
Formula C21H22N2O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-[3-(9H-Carbazol-9-yl)-2-hydroxypropyl]-N-(2-furanylmethyl)-methanesulfonamide

References

1. Hirota T, et al. Science. 2012 Aug 31;337(6098):1094-7.

2. Nangle S, et al. Cell Res. 2013 Dec;23(12):1417-9.

3. St John PC, et al. Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):2040-5.

4. Oshima T, et al. Angew Chem Int Ed Engl. 2015 Jun 8;54(24):7193-7.

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