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Chemical Structure : IU1-47
CAS No.: 670270-31-2
Catalog No.: PC-62623Not For Human Use, Lab Use Only.
IU1-47 is a potent, selective small-molecule inhibitor of USP14 with IC50 of 0.6 uM, shows 10-fold more potent over IU1 and retains specificity for USP14.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 100 mg | $698 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
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IU1-47 is a potent, selective small-molecule inhibitor of USP14 with IC50 of 0.6 uM, shows 10-fold more potent over IU1 and retains specificity for USP14.
IU1-47 accelerates the rate of degradation of wild-type tau, the pathological tau mutants P301L and P301S, and the A152T tau variant in primary neuronal cultures, a specific residue in tau, lysine 174, is critical for the IU1-47-mediated tau degradation by the proteasome.
IU1-47 stimulates autophagic flux in primary neurons.
| M.Wt | 330.856 | |
| Formula | C19H23ClN2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-(1-(4-Chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-(piperidin-1yl)ethanone |
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1. Boselli M, et al. J Biol Chem. 2017 Nov 24;292(47):19209-19225.
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