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XL-9872-106C

Chemical Structure : XL-9872-106C

CAS No.: 2894064-53-8

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XL-9872-106C (XL-106C)

Catalog No.: PC-38156Not For Human Use, Lab Use Only.

XL-9872-106C (XL-106C) is a potent, selective inhibitor of the deubiquitinase (DUB) JOSD1/USP30/UCHL1 with IC50 of 134/390/166 nM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    XL-9872-106C (XL-106C) is a potent, selective inhibitor of the deubiquitinase (DUB) JOSD1/USP30/UCHL1 with IC50 of 134/390/166 nM, respectively.
    XL-9872-106C (XL-106C) displays selectivity against a panel of 41 purified DUB enzymes.
    XL-9872-106C selectively degrade JAK2-V617F and kill JAK2-V617F-expressing Ba/F3 cells.
    XL-9872-106C selectively degrades JAK2-V617F in human AML cells, promotes ubiquitin-mediated proteasomal degradation of JAK2-V617F.
    Targeting of JOSD1 leads to the death of JAK2-V617F-positive primary acute myeloid leukemia (AML) cells.

    Physicochemical Properties

    M.Wt 367.427
    Formula C18H17N5O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 1 Month
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-1-cyano-N-(7-(3,5-dimethylisoxazol-4-yl)benzo[d]thiazol-2-yl)pyrrolidine-3-carboxamide

    References

    1. Jing Yang, et al. Leukemia. 2022 Jan;36(1):210-220.

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