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Chemical Structure : XL-9872-106C
Catalog No.: PC-38156Not For Human Use, Lab Use Only.
XL-9872-106C (XL-106C) is a potent, selective inhibitor of the deubiquitinase (DUB) JOSD1/USP30/UCHL1 with IC50 of 134/390/166 nM, respectively.
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XL-9872-106C (XL-106C) is a potent, selective inhibitor of the deubiquitinase (DUB) JOSD1/USP30/UCHL1 with IC50 of 134/390/166 nM, respectively.
XL-9872-106C (XL-106C) displays selectivity against a panel of 41 purified DUB enzymes.
XL-9872-106C selectively degrade JAK2-V617F and kill JAK2-V617F-expressing Ba/F3 cells.
XL-9872-106C selectively degrades JAK2-V617F in human AML cells, promotes ubiquitin-mediated proteasomal degradation of JAK2-V617F.
Targeting of JOSD1 leads to the death of JAK2-V617F-positive primary acute myeloid leukemia (AML) cells.
| M.Wt | 367.427 | |
| Formula | C18H17N5O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jing Yang, et al. Leukemia. 2022 Jan;36(1):210-220.
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