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Ubiquitin Isopeptidase-IN-G5

Chemical Structure : Ubiquitin Isopeptidase-IN-G5

CAS No.: 108477-18-5

Ubiquitin Isopeptidase-IN-G5 (NSC-144303;NSC 144303;NSC144303)

Catalog No.: PC-42241Not For Human Use, Lab Use Only.

Ubiquitin Isopeptidase-IN-G5 (NSC 144303) is a small molecule inhibitor of ubiquitin-proteasome system by inhibiting the ubiquitin isopeptidases.

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Biological Activity

Ubiquitin Isopeptidase-IN-G5 (NSC 144303) is a small molecule inhibitor of ubiquitin-proteasome system by inhibiting the ubiquitin isopeptidases.
Ubiquitin Isopeptidase-IN-G5 (NSC 144303) induce a unique apoptotic pathway, which includes a Bcl-2-dependent but apoptosome-independent mitochondrial pathway with up-regulation of the BH3-only protein Noxa, stabilization of the IAP antagonist Smac, but also the involvement of the death receptor pathway.

Physicochemical Properties

M.Wt 414.3887
Formula C19H14N2O7S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 31 mg/mL

Chemical Name/SMILES

4H-Thiopyran-4-one, tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-, 1,1-dioxide

References

1. Aleo E, et al. Cancer Res. 2006 Sep 15;66(18):9235-44.

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