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Chemical Structure : LDN-57444
CAS No.: 668467-91-2
Catalog No.: PC-45498Not For Human Use, Lab Use Only.
LDN57444 is a potent, reversible, competitive, active site-directed UCHL1 inhibitor with IC50 of 0.88 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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LDN57444 is a potent, reversible, competitive, active site-directed UCHL1 inhibitor with IC50 of 0.88 uM.
LDN57444 shows weak inhibition on Uch-L3 (IC50> 20 uM).
LDN57444 causes cell death through the apoptosis pathway by decreasing the activity of ubiquitin proteasome system and increasing the levels of highly ubiquitinated proteins, both of which can activate UPR.
| M.Wt | 397.6398 | |
| Formula | C17H11Cl3N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
1H-Indole-2,3-dione, 5-chloro-1-[(2,5-dichlorophenyl)methyl]-, 3-(O-acetyloxime) |
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1. Gong B, et al. Cell. 2006 Aug 25;126(4):775-88.
2. Xie M, et al. J Alzheimers Dis. 2016;49(2):353-63.
3. Tan YY, et al. Mol Cell Biochem. 2008 Nov;318(1-2):109-15.
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