LDN57444 is a potent, reversible, competitive, active site-directed UCHL1 inhibitor with IC50 of 0.88 uM.
LDN57444 shows weak inhibition on Uch-L3 (IC50> 20 uM).
LDN57444 causes cell death through the apoptosis pathway by decreasing the activity of ubiquitin proteasome system and increasing the levels of highly ubiquitinated proteins, both of which can activate UPR.
