Chemical Structure : STIRUR 41
CAS No.:
1123763-21-2
STIRUR 41
(STIRUR-41, STIR UR 41)
Catalog No.: PC-24793Not For Human Use, Lab Use Only.
STIRUR 41 (STIRUR-41, STIR UR 41) is a small molecule USP-7 inhibitor with IC50 of 2.77 uM in HTLA-230 cells, STIRUR 41 (5-10 uM) STIRUR 41 induces a remarkable decrease in USP-7 protein levels in HTLA-230 cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
STIRUR 41 (STIRUR-41, STIR UR 41) is a small molecule USP-7 inhibitor with IC50 of 2.77 uM in HTLA-230 cells, STIRUR 41 (5-10 uM) STIRUR 41 induces a remarkable decrease in USP-7 protein levels in HTLA-230 cells.
STIRUR 41 exerts a strong inhibitory effect on interleukin 8 or N-formyl-methionyl-leucyl-phenylalanine-induced chemotaxis of human neutrophils.
STIRUR 41 is able to counteract the HTLA-230 cells ability to form capillary-like structures, does not affect the viability and tumorigenicity of ACN and HTLA-230 cells, does not induce changes in p38MAPK and phosphop38MAPK levels of ACN and HTLA-230 cells.
Physicochemical Properties
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M.Wt
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350.35
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Formula
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C16H19FN4O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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ethyl 5-(3-(3-fluorophenyl)ureido)-1-(2-hydroxypropyl)-1H-pyrazole-4-carboxylate
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References
1. Marengo B, et al. Oncotarget. 2020 Sep 15;11(37):3459-3472.
2. Elva Morretta, et al. Int J Mol Sci. 2023 May 24;24(11):9200.
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