Chemical Structure : USP30i-3
CAS No.:
2018353-41-6
USP30i-3
Catalog No.: PC-23862Not For Human Use, Lab Use Only.
USP30i-3 is a potent, selective small molecule USP30 inhibitor with IC50 of 21 nM, selective over other DUBs (IC50=250->3000 nM) with exception of USP6 (IC50=60 nM).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
USP30i-3 is a potent, selective small molecule USP30 inhibitor with IC50 of 21 nM, selective over other DUBs (IC50=250->3000 nM) with exception of USP6 (IC50=60 nM).
USP30i-3 (3 µM) enhanced mitophagy in control and PARK2 KO neurons subjected to mitochondrial damage by CCCP. USP30i-3 reduced ROS levels in compromised (either by CCCP or parkin KO) neurons.
In TH-, but not TH+ neurons, 3 µM USP30i-3 reduced HSP60 areas in the absence of CCCP-induced mitochondrial damage, demonstrating a stronger effect of USP30 inhibition on basal mitophagy in the PARK2 KO TH- neurons.
Physicochemical Properties
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M.Wt
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325.80
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Formula
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C18H16ClN3O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2'-chloro-N-(1-cyanopyrrolidin-3-yl)-[1,1'-biphenyl]-4-carboxamide
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References
1. Okarmus J, et al. Cell Death Dis. 2024 Jan 15;15(1):52.
2. Patent WO2016156816 A1.
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