NK036 | USP30 inhibitor | Probechem Biochemicals

Chemical Structure : NK036

NK036 (NK-036)

Catalog No.: PC-24536Not For Human Use, Lab Use Only.

NK036 is a solubility-enhanced derivative of USP30 inhibitor Compound 39 (CMPD-39), has IC50 of 7.4 nM and 4.1 nM for human USP30 (construct 1 (c1) and USP ch3, respectively.

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Biological Activity

NK036 is a solubility-enhanced derivative of USP30 inhibitor Compound 39 (CMPD-39), has IC50 of 7.4 nM and 4.1 nM for human USP30 (construct 1 (c1) and USP ch3, respectively.
NK036 is a potent USP30 inhibitor for co-crystallization studies.

Physicochemical Properties

M.Wt	513.58
Formula	C26H28FN3O5S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-4-fluoro-N-(1-((4-(N-(1-hydroxy-2-methylpropan-2-yl)sulfamoyl)phenyl)amino)-1-oxo-3-phenylpropan-2-yl)benzamide

References

1. Kazi NH, et al. Nat Struct Mol Biol. 2025 May 5.

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NK036 (NK-036)

Biological Activity

Physicochemical Properties

References

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