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8RK64

Chemical Structure : 8RK64

CAS No.: 2705841-52-5

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8RK64 (UCHL1 inhibitor 8RK64)

Catalog No.: PC-49626Not For Human Use, Lab Use Only.

8RK64 is a covalent small molecule inhibitor of ubiquitin carboxy-terminal hydrolase L1 (UCHL1, PGP9.5, PARK5) enzyme with IC50 of 0.32 uM, >80-fold selectivity over UCHL3 and UCHL5.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    8RK64 is a covalent small molecule inhibitor of ubiquitin carboxy-terminal hydrolase L1 (UCHL1, PGP9.5, PARK5) enzyme with IC50 of 0.32 uM, >80-fold selectivity over UCHL3 and UCHL5.
    8RK64 inhibits UCHL1 activity in cells as shown in a DUB profiling experiment in HEK293T cells using a Cy5-Ub-PA probe.

    Physicochemical Properties

    M.Wt 360.40
    Formula C14H16N8O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-N-(5-(2-azidoacetyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)-1-cyanopyrrolidine-3-carboxamide

    References

    1. Raymond Kooij, et al. J Am Chem Soc. 2020 Sep 30;142(39):16825-16841.

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