Catalog No.: PC-49051Not For Human Use, Lab Use Only.
DC-U4106 is a potent, selective small molecule inhibitor of Ubiquitin-specific protease 8 (USP8) with binding KD value of 4.7 uM, DC-U4106 is selective over USP2 and USP7.
DC-U4106 is a potent, selective small molecule inhibitor of Ubiquitin-specific protease 8 (USP8) with binding KD value of 4.7 uM, DC-U4106 is selective over USP2 and USP7.
DC-U4106 could target the ubiquitin pathway and facilitate the degradation of Erα inwestern blotting and immunoprecipitation assays.
DC-U4106 also significantly inhibited tumor growth with minimal toxicity in a xenograft tumor model.
DC-U4106 is a promising drug candidate and targeting the USP8-ERα complex for treat ER-positive or drug-resistant breast cancer.
