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Chemical Structure : DC-U4106
Catalog No.: PC-49051Not For Human Use, Lab Use Only.
DC-U4106 is a potent, selective small molecule inhibitor of Ubiquitin-specific protease 8 (USP8) with binding KD value of 4.7 uM, DC-U4106 is selective over USP2 and USP7.
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DC-U4106 is a potent, selective small molecule inhibitor of Ubiquitin-specific protease 8 (USP8) with binding KD value of 4.7 uM, DC-U4106 is selective over USP2 and USP7.
DC-U4106 could target the ubiquitin pathway and facilitate the degradation of Erα inwestern blotting and immunoprecipitation assays.
DC-U4106 also significantly inhibited tumor growth with minimal toxicity in a xenograft tumor model.
DC-U4106 is a promising drug candidate and targeting the USP8-ERα complex for treat ER-positive or drug-resistant breast cancer.
| M.Wt | 525.565 | |
| Formula | C29H27N5O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yucheng Tian, et al. J Med Chem. 2022 Jul 5. doi: 10.1021/acs.jmedchem.2c00013.
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