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Chemical Structure : BML-260
Catalog No.: PC-49744Not For Human Use, Lab Use Only.
BML-260 (BML260) is a potent inhibitor of dual-specific phosphatase JSP-1 (JNK Stimulatory Phosphatase-1, DUSP22) and stimulator of uncoupling protein 1 (UCP-1) expression in adipocytes.
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BML-260 (BML260) is a potent inhibitor of dual-specific phosphatase JSP-1 (JNK Stimulatory Phosphatase-1, DUSP22) and stimulator of uncoupling protein 1 (UCP-1) expression in adipocytes.
BML-260 activates UCP1 expression (both the mRNA level and the protein level) and increases mitochondrial activity in brown adipocytes.
BML-260 stimulates the expression of UCP1 in adipocytes in a JSP-1 independent manner.
BML-260 upregulates thermogenic and muscle program genes.
BML-260 induces UCP1 expression in white adipocytes and enhances thermogenesis, activates UCP1 and increases thermogenesis in vivo.
JSP-1 is a dual-specific phosphatase encoded by DUSP22 (dual specificity phosphatase 22), which is also known as JKAP (JNK pathway-associated phosphatase), JSP-1 is a JNK activator, and a proposed target for the treatment of inflammatory and proliferative disorders associated with dysfunctional JNK signaling.
| M.Wt | 341.40 | |
| Formula | C17H11NO3S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Feng Z, et al. Theranostics. 2019 May 26;9(12):3501-3514.
2. Albayrak E, et al. J Cell Biochem. 2022 Dec;123(12):2009-2029.
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