C598-0556 | USP10 inhibitor | Probechem Biochemicals

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Chemical Structure : C598-0556

C598-0556 (USP10 inhibitor)

Catalog No.: PC-38771Not For Human Use, Lab Use Only.

C598-0556 is a selective, small molecule inhibitor of USP10, inhibits USP10 comparably to HBX19818 (IC50=10 uM), with no inhibition against USP7 (IC50>100 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

C598-0556 is a selective, small molecule inhibitor of USP10, inhibits USP10 comparably to HBX19818 (IC50=10 uM), with no inhibition against USP7 (IC50>100 uM).
Small molecule inhibition of USP10 leads to degradation of SYK and targeted killing of activated SYK-driven cells.
C598-0556 induces degradation of SYK in AML cells.

Physicochemical Properties

M.Wt	481.012
Formula	C27H30ClFN4O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	9-chloro-N-(3-(4-(2-fluorophenyl)piperazin-1-yl)propyl)-5,6,7,8-tetrahydroacridine-3-carboxamide

References

1. Jing Yang, et al. Br J Cancer. 2020 Apr 14; 122(8): 1175–1184.

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