Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
    English |     Chinese

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-Proteasome/Ubiquitin-Deubiquitinase (DUB)-ST-539
ST-539

Chemical Structure : ST-539

CAS No.: 1040754-67-3

Add to Favorites

ST-539 (ST539)

Catalog No.: PC-23860Not For Human Use, Lab Use Only.

ST-539 is a potent mitophagy inducer and selective USP30 inhibitor (IC50=0.37 uM), does not inhibit USP1, 8 and 9 at 10 uM.

Packing Price Stock Quantity
50 mg Get quote
100 mg Get quote
250 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ST-539 is a potent mitophagy inducer and selective USP30 inhibitor (IC50=0.37 uM), does not inhibit USP1, 8 and 9 at 10 uM.
ST-539 restored TIM23 and TOM40 degradation in in Hela-Parkin cells, in which PINK1 and Parkin are required.
ST-539 has minimal effect on mitochondrial function in cells.
ST-539 (25 mg/kg, i.p.) induced tissue specific mitophagy in vivo.

Physicochemical Properties

M.Wt 529.66
Formula C30H31N3O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(1-((5-(N-(tert-butyl)sulfamoyl)naphthalen-1-yl)amino)-1-oxo-3-phenylpropan-2-yl)benzamide

References

1. Luo H, et al. Acta Physiol (Oxf). 2021 Jul;232(3):e13666.

2. Kluge AF, et al. Bioorganic & medicinal chemistry letters. 2018;28(15):2655–2659.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: