Catalog No.: PC-23861Not For Human Use, Lab Use Only.
USP30i-37 is a potent, selective small molecule USP30 inhibitor with IC50 of 48 nM, selective over other DUBs (IC50=400->3000 nM) with exception of USP6 (IC50=95 nM).
USP30i-37 is a potent, selective small molecule USP30 inhibitor with IC50 of 48 nM, selective over other DUBs (IC50=400->3000 nM) with exception of USP6 (IC50=95 nM).
USP30i-37 (3 µM) enhanced mitophagy in control and PARK2 KO neurons subjected to mitochondrial damage by CCCP. USP30i-37 reduced ROS levels in compromised (either by CCCP or parkin KO) neurons.
In TH-, but not TH+ neurons, 3 µM USP30i-37 reduced HSP60 areas in the absence of CCCP-induced mitochondrial damage, demonstrating a stronger effect of USP30 inhibition on basal mitophagy in the PARK2 KO TH- neurons.
