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USP30-I-1

Chemical Structure : USP30-I-1

CAS No.: 2511541-78-7

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USP30-I-1

Catalog No.: PC-23736Not For Human Use, Lab Use Only.

USP30-I-1 is a potent, selective and covalent inhibitor of mitochondrial deubiquitinating (DUB) enzyme USP30 with IC50 of 94 nM, shows no significant activity against other 40 endogenous DUBs.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

USP30-I-1 is a potent, selective and covalent inhibitor of mitochondrial deubiquitinating (DUB) enzyme USP30 with IC50 of 94 nM, shows no significant activity against other 40 endogenous DUBs.
USP30-I-1 is a selective and potent inhibitor of USP30 at concentrations ≤1 µM.
USP30-I-1 inhibited USP30 in a dose-dependent manner, with an IC50 of 4 nM in fluorescence intensity measurements.
USP30-I-1 binds to the catalytic cysteine (Cys77) of USP30.

Physicochemical Properties

M.Wt 321.34
Formula C17H15N5O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-Oxazolecarboxamide, N-[(3R,5R)-1-cyano-5-methyl-3-pyrrolidinyl]-5-(3-cyanophenyl)-

References

1. Darragh P O'Brien, et al. J Proteome Res. 2025 Jan 13. doi: 10.1021/acs.jproteome.4c00618.

2. O'Brien D P, et al. bioRxiv, 2024: 2024.07. 20.604388.

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