Chemical Structure : USP30-I-1
CAS No.:
2511541-78-7
USP30-I-1
Catalog No.: PC-23736Not For Human Use, Lab Use Only.
USP30-I-1 is a potent, selective and covalent inhibitor of mitochondrial deubiquitinating (DUB) enzyme USP30 with IC50 of 94 nM, shows no significant activity against other 40 endogenous DUBs.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
USP30-I-1 is a potent, selective and covalent inhibitor of mitochondrial deubiquitinating (DUB) enzyme USP30 with IC50 of 94 nM, shows no significant activity against other 40 endogenous DUBs.
USP30-I-1 is a selective and potent inhibitor of USP30 at concentrations ≤1 µM.
USP30-I-1 inhibited USP30 in a dose-dependent manner, with an IC50 of 4 nM in fluorescence intensity measurements.
USP30-I-1 binds to the catalytic cysteine (Cys77) of USP30.
Physicochemical Properties
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M.Wt
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321.34
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Formula
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C17H15N5O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-Oxazolecarboxamide, N-[(3R,5R)-1-cyano-5-methyl-3-pyrrolidinyl]-5-(3-cyanophenyl)-
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References
1. Darragh P O'Brien, et al. J Proteome Res. 2025 Jan 13. doi: 10.1021/acs.jproteome.4c00618.
2. O'Brien D P, et al. bioRxiv, 2024: 2024.07. 20.604388.
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