Chemical Structure : USP7 inhibitor X36
CAS No.:
3034567-54-6
USP7 inhibitor X36
Catalog No.: PC-22885Not For Human Use, Lab Use Only.
USP7 inhibitor X36 is a potent, selective and orally active USP7 inhibitor with IC50 of 64.5 nM, shows no activity against a panel of 9 DUBs including USP47.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
USP7 inhibitor X36 is a potent, selective and orally active USP7 inhibitor with IC50 of 64.5 nM, shows no activity against a panel of 9 DUBs including USP47.
X36 (100 mg/kg, p.o.) exerted in vivo antitumor activity, probably through modulating immunity in the colons tumor-bearing C57BL/6J mice.
X36 suppressed tumor growth probably through enhancement of the antitumor immunity response by upregulation of tumor-killing CD8+ T, NK, and NKT cells and downregulation of immunosuppressive Tregs and MDSCs in the tumor microenvironment.
Physicochemical Properties
|
M.Wt
|
548.02
|
|
Formula
|
C29H27ClFN5O3
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
6-((1-(2-Chloro-4-(furan-2-yl)benzyl)-4-hydroxypiperidin-4-yl)methyl)-3-(4-fluorophenyl)-2-methyl-2,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
|
References
1. Xing Li, et al. J Med Chem. 2022 Dec 22;65(24):16622-16639.
Contact Us
sales@probechem.com
