Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : USP7 inhibitor X36
Catalog No.: PC-22885Not For Human Use, Lab Use Only.
USP7 inhibitor X36 is a potent, selective and orally active USP7 inhibitor with IC50 of 64.5 nM, shows no activity against a panel of 9 DUBs including USP47.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
USP7 inhibitor X36 is a potent, selective and orally active USP7 inhibitor with IC50 of 64.5 nM, shows no activity against a panel of 9 DUBs including USP47.
X36 (100 mg/kg, p.o.) exerted in vivo antitumor activity, probably through modulating immunity in the colons tumor-bearing C57BL/6J mice.
X36 suppressed tumor growth probably through enhancement of the antitumor immunity response by upregulation of tumor-killing CD8+ T, NK, and NKT cells and downregulation of immunosuppressive Tregs and MDSCs in the tumor microenvironment.
| M.Wt | 548.02 | |
| Formula | C29H27ClFN5O3 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Xing Li, et al. J Med Chem. 2022 Dec 22;65(24):16622-16639.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
