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HBX41108

Chemical Structure : HBX41108

CAS No.: 924296-39-9

HBX41108 (HBX 41108)

Catalog No.: PC-20202Not For Human Use, Lab Use Only.

HBX41108 is a specific small-molecule inhibitor of USP7/HAUSP ubiquitin protease with IC50 of 424 nM for inhibition of Ub-AMC hydrolysis by USP7.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

HBX41108 is a specific small-molecule inhibitor of USP7/HAUSP ubiquitin protease with IC50 of 424 nM for inhibition of Ub-AMC hydrolysis by USP7.
HBX41108 shows little to no activity against a panel of serine, aspartic, and metalloproteases, calpain-1 (IC50 > 10 μmol/L), and cathepsins B, L, and S (IC50 > 1 μmol/L).
HBX 41108 inhibits USP7-mediated p53 deubiquitination (IC50=0.8 uM), increases p53 levels in a nongenotoxic manner.
HBX41108 (0.1-3 uM) inhibits HCT116 cancer cell growth and induces apoptotic cell death, induces apoptosis in a p53-dependent manner.

Physicochemical Properties

M.Wt 266.64
Formula C13H3ClN4O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile

References

1. Colland F, et al. Mol Cancer Ther. 2009 Aug;8(8):2286-95.

2. Lee KW, et al. J Biol Chem. 2013 Nov 15;288(46):32886-96.

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