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Chemical Structure : HBX41108
CAS No.: 924296-39-9
Catalog No.: PC-20202Not For Human Use, Lab Use Only.
HBX41108 is a specific small-molecule inhibitor of USP7/HAUSP ubiquitin protease with IC50 of 424 nM for inhibition of Ub-AMC hydrolysis by USP7.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 100 mg | $698 | In stock | |
| 1 g | Get quote |
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HBX41108 is a specific small-molecule inhibitor of USP7/HAUSP ubiquitin protease with IC50 of 424 nM for inhibition of Ub-AMC hydrolysis by USP7.
HBX41108 shows little to no activity against a panel of serine, aspartic, and metalloproteases, calpain-1 (IC50 > 10 μmol/L), and cathepsins B, L, and S (IC50 > 1 μmol/L).
HBX 41108 inhibits USP7-mediated p53 deubiquitination (IC50=0.8 uM), increases p53 levels in a nongenotoxic manner.
HBX41108 (0.1-3 uM) inhibits HCT116 cancer cell growth and induces apoptotic cell death, induces apoptosis in a p53-dependent manner.
| M.Wt | 266.64 | |
| Formula | C13H3ClN4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile |
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1. Colland F, et al. Mol Cancer Ther. 2009 Aug;8(8):2286-95.
2. Lee KW, et al. J Biol Chem. 2013 Nov 15;288(46):32886-96.
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