GSK2643943A is a specific, cell penetrant small molecule inhibitor of deubiquitinating enzyme USP20 with IC50 of 160 nM (USP20/Ub-Rho).
GSK2643943A blocked the USP20-mediated cleavage of protein-ubiquitin bonds.
GSK2643943A (1 uM) influences oHSV-1 T1012G productive infection and viability in SCC9 cells.
GSK2643943A treatment potentiated oHSV-1-induced oncolysis in SCC9 tumors.
GSK2643943A treatment boosted the anti-tumor effects of oHSV-1 T1012G in SCC7 tumors in mice.
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