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Chemical Structure : b-AP15
CAS No.: 1009817-63-3
Catalog No.: PC-20656Not For Human Use, Lab Use Only.
b-AP15 is a specific inhibitor of ubiquitin-specific-processing protease 14 (USP14) and ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5), inhibits DUB activity in purified 19S proteasomes with IC50 of 2.1 uM.
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|---|---|---|---|
| 100 mg | $198 | In stock | |
| 200 mg | $298 | In stock | |
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b-AP15 is a specific inhibitor of ubiquitin-specific-processing protease 14 (USP14) and ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5), inhibits DUB activity in purified 19S proteasomes with IC50 of 2.1 uM.
b-AP15 exhibits little or no activity against several other DUBs.
b-AP15 induces tumor cell apoptosis that is insensitive to TP53 status and overexpression of the apoptosis inhibitor BCL2, blocks growth and induces apoptosis in MM cells.
b-AP15 blocks tumor progression in vivo in mice and prevents organ infiltration in mouse models of myeloid leukemia.
| M.Wt | 419.39 | |
| Formula | C22H17N3O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(3E,5E)-3,5-Bis[(4-nitrophenyl)methylene]-1-(1-oxo-2-propen-1-yl)-4-piperidinone |
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1. D'Arcy P, et al. Nat Med. 2011 Nov 6;17(12):1636-40.
2. Wang X, et al. Mol Pharmacol. 2014 Jun;85(6):932-45.
3. Tian Z, et al. Blood. 2014 Jan 30;123(5):706-16.
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