Catalog No.: PC-20656Not For Human Use, Lab Use Only.
b-AP15 is a specific inhibitor of ubiquitin-specific-processing protease 14 (USP14) and ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5), inhibits DUB activity in purified 19S proteasomes with IC50 of 2.1 uM.
b-AP15 is a specific inhibitor of ubiquitin-specific-processing protease 14 (USP14) and ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5), inhibits DUB activity in purified 19S proteasomes with IC50 of 2.1 uM. b-AP15 exhibits little or no activity against several other DUBs. b-AP15 induces tumor cell apoptosis that is insensitive to TP53 status and overexpression of the apoptosis inhibitor BCL2, blocks growth and induces apoptosis in MM cells. b-AP15 blocks tumor progression in vivo in mice and prevents organ infiltration in mouse models of myeloid leukemia.
