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CAS-12290-201

Chemical Structure : CAS-12290-201

CAS No.:

CAS-12290-201

Catalog No.: PC-20001Not For Human Use, Lab Use Only.

CAS-12290-201 is a potent and selective inhibitor of deubiquitinating enzyme (DUB) VCPIP1 with IC50 of 70 nM, covalently and specificly targets the catalytic cysteine of VCPIP1 with little to no activity toward other cellular DUBs.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

CAS-12290-201 is a potent and selective inhibitor of deubiquitinating enzyme (DUB) VCPIP1 with IC50 of 70 nM, covalently and specificly targets the catalytic cysteine of VCPIP1 with little to no activity toward other cellular DUBs.

Physicochemical Properties

M.Wt 309.73
Formula C14H13ClFN3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-((1-(2-chloroacetyl)azetidin-3-yl)methyl)-7-fluoroquinazolin-4(3H)-one

References

1. Wai Cheung Chan, et al. Nat Commun. 2023 Feb 8;14(1):686.

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