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CAS-12290-201

Chemical Structure : CAS-12290-201

CAS No.: 3025298-68-1

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CAS-12290-201 (VCPIP1 inhibitor)

Catalog No.: PC-20001Not For Human Use, Lab Use Only.

CAS-12290-201 is a potent and selective inhibitor of deubiquitinating enzyme (DUB) VCPIP1 with IC50 of 70 nM, covalently and specificly targets the catalytic cysteine of VCPIP1 with little to no activity toward other cellular DUBs.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CAS-12290-201 is a potent and selective inhibitor of deubiquitinating enzyme (DUB) VCPIP1 with IC50 of 70 nM, covalently and specificly targets the catalytic cysteine of VCPIP1 with little to no activity toward other cellular DUBs.

    Physicochemical Properties

    M.Wt 309.73
    Formula C14H13ClFN3O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-((1-(2-chloroacetyl)azetidin-3-yl)methyl)-7-fluoroquinazolin-4(3H)-one

    References

    1. Wai Cheung Chan, et al. Nat Commun. 2023 Feb 8;14(1):686.

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