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Chemical Structure : PR-619
CAS No.: 2645-32-1
Catalog No.: PC-20403Not For Human Use, Lab Use Only.
PR-619 (PR619) is a broad-spectrum, reversible deubiquitinating enzymes (DUBs) inhibitor with IC50 of 3.93 uM-8.87 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $88 | In stock | |
| 50 mg | $138 | In stock | |
| 100 mg | $218 | In stock | |
| 250 mg | Get quote |
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PR-619 (PR619) is a broad-spectrum, reversible deubiquitinating enzymes (DUBs) inhibitor with IC50 of 3.93 uM-8.87 uM.
PR-619 showed limited activity against other families of proteases, including representative examples of other families of cysteine proteases.
PR-619 increased caspase-8 ubiquitination and caspase-8 enzymatic activity and sensitized normal fibroblasts to TRAIL-mediated apoptosis.
PR-619 reduced Smad4 expression and suppresses renal fibrosis in mice with unilateral ureteral obstruction.
| M.Wt | 223.27 | |
| Formula | C7H5N5S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2,6-diaminopyridine-3,5-bis(thiocyanate) |
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1. Altun M, et al. Chem Biol. 2011 Nov 23;18(11):1401-12.
2. Crowder RN, et al. J Biol Chem. 2016 Mar 11;291(11):5960-5970.
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