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Neutral Red

Chemical Structure : Neutral Red

CAS No.: 553-24-2

Neutral Red

Catalog No.: PC-20480Not For Human Use, Lab Use Only.

Neutral Red is a nitrogenous pH-indicator that can stains lysosomes red, also is a selective, uncompetitive USP4 inhibitor with IC50 of 50 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Neutral Red is a nitrogenous pH-indicator that can stains lysosomes red, also is a selective, uncompetitive USP4 inhibitor with IC50 of 50 uM.
Neutral Red displays no effective activity on other DUBs (YOD1, USP5, UCHL1, and USP14).
Neutral Red inhibited the deubiquitinating activity of USP4 in colon cancer cells.
Neutral Red affected the protein stability of β-catenin, and the target genes expression of β-catenin.
Neutral Red significantly reduced colony formation and cell migration, reduced the tumor volume in mouse xenograft models.

Physicochemical Properties

M.Wt 288.78
Formula C15H16N4.ClH
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2,8-Phenazinediamine, N8,N8,3-trimethyl-, monohydrochloride

References

1. Nguyen HH, et al. Cell Physiol Biochem. 2019;53(1):157-171.

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